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since 1980



K41 タイプⅡコラーゲン液(K41 タイプⅡ液)

容液量: 8 ml(防腐剤無し)      

コラーゲン濃度: 0.3 %(3mg/ml)

形状: 溶液 (凍結)

保存: 短期-20 ℃ 長期-40 ℃以下 

原料: ウシ関節軟骨

抽出: 酸・ペプシン処理

精製: 独自精製

K42 タイプⅡコラーゲン末(K42 タイプⅡ末)

含量: 24 mg/v      

形状: 凍結乾燥品

保存: 短期-20 ℃ 長期-40 ℃以下 

原料: ウシ関節軟骨

抽出: 酸・ペプシン処理

精製: 独自精製


K43 ニワトリタイプⅡコラーゲン末

含量: 10 mg/v       

形状: 凍結乾燥品

保存: 短期-20 ℃ 長期-40 ℃以下

原料: ニワトリ胸部軟骨

抽出: 酸・ペプシン処理

精製: 独自精製


K44 ブタタイプⅡコラーゲン末

含量: 10 mg/v

形状: 凍結乾燥       



本品は関節軟骨由来で実験動物に膠原病の一種で全身性自己免疫疾患である関節リウマチモデル (コラーゲン誘導性関節炎collagen-induced arthritis : CIA)を惹起させます。

1981 年に世界で最初の製品化しました。​​


K45 ラットELISA用 タイプⅡコラーゲン

含量: 200μg

形状: 溶液 (凍結)

K46 ウシELISA用 タイプⅡコラーゲン

含量: 100μg

形状: 溶液 (凍結)

K47 ニワトリELISA用 タイプⅡコラーゲン

含量: 100μg

形状: 溶液 (凍結)

K48 ブタELISA用 タイプⅡコラーゲン

含量: 100μg

形状: 溶液 (凍結)

K49 ヒトELISA用 タイプⅡコラーゲン

含量: 100μg

形状: 溶液 (凍結)

K49 サル タイプⅡコラーゲン

含量: 500μg


・「K72 抗タイプⅡコラーゲン抗体測定システムELISA(ラット用)」




Nemoto N., et al. (2019) Analysis of intestinal immunity and flora in a collagen-induced mouse arthritis model: differences during arthritis progression.Int Immunol. 2019 Sep 28. pii: dxz058. 

Tomimori Y., et al. (2019) ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice. Eur J Pharmacol. 2019 Aug 5;856:172403.

Hoshino N., et al. (2019) Role of Anti-Fractalkine Antibody in Suppression of Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis.Arthritis Rheumatol. 2019 Feb;71(2):222-231.

Tsubosaka Y., et al. (2019) Hematopoietic prostaglandin D synthase-derived prostaglandin D2 ameliorates adjuvant-induced joint inflammation in mice. FASEB J. 2019 Jun;33(6):6829-6837.

Hiroyuki Y., et al. (2019) Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys. International Journal of Rheumatology Volume 2019, Article ID 5710340, 9 pages

Mohammad A., et al. (2019) Self-organization of hepatocyte morphogenesis depending on the size of collagen microbeads relative to hepatocytes. Biofabrication, Volume 11, Number 3

Minoru F., et al. (2015) Leucine-rich α2 -glycoprotein as a potential biomarker for joint inflammation during anti-interleukin-6 biologic therapy in rheumatoid arthritis. Arthritis & Rheumatology 67(8):2056-2060.


Hirota M., et al. (2016) Chemically Modified Interleukin-6 Aptamer InhibitsDevelopment of Collagen-Induced Arthritis in Cynomolgus Monkeys. Nucleic Acid Therapeutics 26(1):10-19.

Totsuka R., et al. (2016) Effects of VLA-1 Blockade on Experimental Inflammation in Mice. Kobe J Med Sci. 5;62(2):E27-37.


Sekine C., et al. (2014) Macrophage-derived delta-like protein 1 enhances interleukin-6 and matrix metalloproteinase 3 production by fibroblast-like synoviocytes in mice with collagen-induced arthritis. Arthritis Rheumatol. 66(10):2751-2761.


Uotsu Nobuo, et al. (2016) Suppression of Arthritis Progression with Lutein Extracted from Tagetes erecta in Collagen-Induced Arthritis Model Rats. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 16 (8):134-141.


Ito H., et al. (2016) Prokineticin 2 antagonist, PKRA7 suppresses arthritis in mice with collagen-induced arthritis. BMC Musculoskelet Disord. 17:387.


ShingoSugahara, et al. (2018) Integrin, alpha9 subunit blockade suppresses collagen-induced arthritis with minimal systemic immunomodulation. European Journal of Pharmacology 833: 320-327.


Kato G., et al. (2015) The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study. Arthritis Res Ther. 17(1): 251.


Yokoyama W., et al. (2014) Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice. Arthritis Res Ther. 16(5):445.


Tanimoto A., et al. (2015) Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo. Inflamm Res. 64(1):41-51.


Tanaka M., et al. (2016) Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation. Int J Rheumatol. 8938916.


Otsuki N., et al. (2015) Modulation of immunological responses and amelioration of collagen-induced arthritis by the novel roxithromycin derivative 5-I. Mod Rheumatol. 25(4):562-70.


Yoshida H., et al. (2018) Anti-interleukin-6 receptor antibody prevents loss of bone structure and bone strength in collagen-induced arthritis mice. Scand J Rheumatol. 47(5):384-391.


Mizuno M., et al. (2017) The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models. PLoS One. 12(2):e0173032.


Iizuka M., et al. (2014) Suppression of collagen-induced arthritis by oral administration of transgenic rice seeds expressing altered peptide ligands of type II collagen. Plant Biotechnol J. 12(8):1143-52.


Suzuki M., et al. (2015) Blockade of interleukin-6 receptor enhances the anti-arthritic effect of glucocorticoids without decreasing bone mineral density in mice with collagen-induced arthritis. Clin Exp Immunol. 182(2):154-61.


Hoshino-Negishi K., et al. (2018) Anti-Fractalkine Antibody Suppresses Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis. Arthritis Rheumatol. doi: 10.1002/art.40688.


Takahashi Y., et al. (2014) Prophylactic and therapeutic effects of Acanthopanax senticosus Harms extract on murine collagen-induced arthritis. Phytother Res. 28(10):1513-9.


Fukuda S., et al. (2014) Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis. BMC Musculoskelet Disord. 15:275.


Tanaka K., et al. (2014) Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. Clin Exp Immunol. 175(2):172-80.


Murakoshi M., et al. (2017) Discovery and pharmacological effects of a novel GPR142 antagonist. J Recept Signal Transduct Res. 37(3):290-296.


Gao S., et al. (2017) Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis. J Ethnopharmacol. 196:39-46.


Iizuka M., et al. (2014) Prophylactic effect of the oral administration of transgenic rice seeds containing altered peptide ligands of type II collagen on rheumatoid arthritis. Biosci Biotechnol Biochem. 78(10):1662-8.


Tatsuya Tamura, et al. (2016) Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models. Arthritis Res Ther. 18: 121.


Murata Y., et al. (2014) Autoimmune animal models in the analysis of the CD47-SIRPα signaling pathway. Methods. 65(2):254-9.


Oike T., et al. (2017) Stat3 as a potential therapeutic target for rheumatoid arthritis. Sci Rep. 7(1):10965.


Koji Sakuraba, et al. (2016) Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice. Arthritis Research & Therapy 18:188.

Type Ⅱ Collagen:

Kumai T., et al. (2019) A novel, self-assembled artificial cartilage-hydroxyapatite conjugate for combined articular cartilage and subchondral bone repair: histopathological analysis of cartilage tissue engineering in rat knee joints. Int J Nanomedicine. 2019 Feb 19;14:1283-1298.

Kanagawa H., et al. (2015) Mycobacterium tuberculosis promotes arthritis development through Toll-like receptor 2. J Bone Miner Metab. 33(2):135-41.


Shimomura S., et al. (2018) Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model. Int J Mol Sci. 19(6). pii: E1653.


Kato T., et al. (2017) JTE-852, a novel spleen tyrosine kinase inhibitor, blocks immunoglobulin G-mediated cellular responses and autoimmune reactions in vivo. Life Sci. 191:166-174.


Gao J., et al. (2015) A disintegrin and metallproteinase 15 knockout decreases migration of fibroblast-like synoviocytes and inflammation in rheumatoid arthritis. Mol Med Rep. 11(6):4389-96.


Inoue H., et al. (2014) Sonoporation-mediated transduction of siRNA ameliorated experimental arthritis using 3 MHz pulsed ultrasound. Ultrasonics. 54(3):874-81.


1)山津功,千葉健一. Ⅱ型コラーゲン関節炎. In:大河内和雄 編
  炎症とアレルギー 東京:広川書店 1993: 163-175

2)柿本穀一, 小俣節子. アジュバンド, コラーゲン関節炎の誘導.
  In: 高津聖志, 瀧伸介 編 免疫研究の基礎知識 東京:羊土社
  1995: 283-290.

3) F.Kato,et al.:Annals of the Rheumatic Diseases 1996;55:535-539.

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